Oral Perampanel for the Treatment of Super-Refractory Status Epilepticus

Oral Perampanel for the Treatment of Super-Refractory Status Epilepticus

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A 72-year-old man presented with a super-refractory partial status epilepticus following evacuation of a right subdural hematoma.He failed Skateboards to respond to treatment with high doses of intravenous valproic acid, Levetiracetam, Lacosamide, Thiopental, and Midazolam.He was given 4 mg of Perampanel orally via nasogastric tube and the Collections dose was rapidly increased to 8 mg after 12 hours with cessation of clinical and electrical seizures.Other antiepileptic drugs were tapered progressively with an excellent clinical outcome.